I. Basic Information

Chemical Structure：

It is composed of 43 amino acids, with the sequence: NH2-acetyl-Ser-Asp-Ala-Gly-Glu-Gly-Glu-Ala-Asn-Pro-Val-Asp-Thr-Val-Pro-Leu-Gly-Lys-Pro-Val-Lys-Glu-Lys-Leu-Leu-Lys-Asp-Val-Pro-Gly-Glu-Glu-Ala-Glu-Asp-Leu-Ala-Gln-Gly-Asp-Lys-Gly-Phe-Val-Gln-COOH.

The molecular weight is approximately 4965 Da. It usually exists in the form of acetate, has good stability, and needs to be stored under refrigeration.

Mechanism of action：

·Promote cell migration: Induce the migration of endothelial cells, fibroblasts, and stem cells to the injury site, accelerating tissue repair.

·Regulate actin: Bind to and sequester actin monomers, regulate cytoskeletal reorganization, and promote wound healing and angiogenesis.

·Anti - inflammatory and antioxidant: Reduce the release of inflammatory factors (such as IL - 6, TNF - α), protecting cells from oxidative stress damage.

·Promote angiogenesis: Stimulate the proliferation of endothelial cells, form new blood vessels, and improve the blood supply to damaged tissues.

II. Potential Uses (Based on Research and Practice)

Musculoskeletal Repair

·Tendon/Ligament Injury: For conditions like Achilles tendonitis and rotator cuff injury, research shows it can accelerate tendon fiber regeneration and reduce scar tissue formation.

·Muscle Strain: It promotes muscle cell repair, shortens the post - exercise recovery time, and is commonly seen in athletes and fitness enthusiasts.

·Bone Injury: It may enhance osteoblast activity and assist in fracture healing (there is substantial evidence from animal experiments).

Skin and Wound Healing

·Improve the healing rate of chronic wounds (such as diabetic foot ulcers), burns, or surgical incisions, and reduce scar formation.

·Promote the activation of hair follicle stem cells, which may be used for the treatment of hair loss (supported by some in vitro studies).

Respiratory System Repair

·Animal experiments show that it can reduce pulmonary inflammation (such as asthma, pulmonary fibrosis) and promote the repair of alveolar epithelial cells.

Other fields

·Nerve repair: It may promote the regeneration of nerve cells and improve the functional recovery after brain injury or stroke (effective in animal models).

·Corneal repair: It is used to treat corneal injuries and dry eye, and accelerate the regeneration of epithelial cells (preclinical ophthalmic research).

III. Usage and Dosage

Administration Route

·Injection: Subcutaneous or intramuscular injection is preferred, and intravenous injection should be avoided (it may cause transient discomfort).

·Topical Application: It can be made into gels or solutions for skin wounds (aseptic operation must be ensured).

Dosage RangeGeneral Repair: The commonly used dosage for adults is 2 - 4 mg/week for 4 - 6 consecutive weeks. After that, it can be reduced to the maintenance dosage (1 - 2 mg/week).

Severe injury: Some studies have attempted 5 - 10 mg/week, but individual tolerance needs to be carefully evaluated.

Cycle: It usually needs to last for several weeks to months, and the effect accumulates with the extension of the treatment course.

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