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CJC1295 5mg+IPAM 5mg usually refers to the combination of the two (for example, a single preparation contains 5mg of each of the two components), and its effect is mainly achieved through the coordinated regulation of the secretion of growth hormone (GH) and insulin - like growth factor - 1 (IGF - 1).
Product Details
Synergistically promote the secretion of growth hormone (GH)
1. Complementary Mechanisms of Action
CJC1295:
·Without DAC: As a growth hormone - releasing hormone (GHRH) analog, it acts directly on the pituitary gland to stimulate the synthesis and secretion of GH. However, its half - life is short (frequent injections are required).
·With DAC: It binds to albumin through a drug - affinity complex (DAC), extending the half - life to approximately 8 days, which can provide a continuous stimulation of basal GH secretion.
Ipamorelin:
·It belongs to the growth hormone - releasing peptide (GHRP). By activating the growth hormone - secreting receptor (GHS - R) in the pituitary gland, it promotes the pulsatile release of GH (especially the physiological peak during night - time sleep). At the same time, it inhibits somatostatin (a hormone that negatively feedback - inhibits GH), thus enhancing GH secretion through a dual - action mechanism.
Effects on Metabolism and Body Composition
1. Promote Muscle Synthesis and Repair
·Enhanced Protein Synthesis: GH and IGF-1 can activate the mTOR pathway, promote the uptake of amino acids by skeletal muscle cells, and accelerate protein synthesis, which may be used in research on muscle atrophy, sports injury repair, etc.
·Increase in Muscle Mass: The combined use may increase muscle weight and strength more significantly than single-drug use (animal experimental data need to be combined).
2. Accelerate Fat Lipolysis
·Increased Lipolysis: GH promotes the breakdown of fat into free fatty acids for energy by activating hormone - sensitive lipase (HSL) in adipocytes. Especially under calorie - restricted conditions, it may more effectively reduce body fat.
·Improve Body Composition: Research shows that the combination of GHRH + GHRP can reduce the body fat percentage while preserving or increasing lean body mass, making it suitable for obesity or metabolic syndrome models.
3. Impact on Circadian Rhythm
·Ipamorelin can enhance nocturnal GH pulsatile secretion (close to the physiological pattern), while CJC - 1295 (especially With DAC) provides a continuous basal level of GH stimulation. The combination of the two may be closer to the body's natural GH secretion rhythm and reduce interference with the endocrine system.
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