I. Basic Information

Chemical Structure: The amino acid sequence is His-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2, and acetate modification is used to improve bioavailability.

CAS Number: 146402-23-9 (free base); CAS number for the acetate form: 146402-25-1.

Molecular Weight: Approximately 811.9 g/mol for the free base, slightly higher for the acetate.

Target of action: Binds to and activates the Growth Hormone Secretagogue Receptor (GHS-R), which is mainly distributed in the pituitary gland and hypothalamus, promoting the release of GH; simultaneously acts on the gastrointestinal tract and central nervous system, affecting appetite and metabolism.

II. Mechanism of Action

Core Mechanism:

Activation of the Growth Hormone - IGF-1 Axis:

Stimulate the anterior pituitary to release growth hormone, thereby promoting the liver to synthesize IGF-1, playing roles in promoting growth and regulating metabolism (such as promoting protein synthesis and fat breakdown).

Act synergistically with endogenous growth hormone - releasing hormone (GHRH) to enhance the GH - secreting effect.

Appetite Regulation: By acting on the appetite center in the hypothalamus, increase hunger (appetizing effect), which may be related to promoting the secretion of ghrelin or enhancing its effect.

III. Main Uses

Sarcopenia and Obesity:

Preliminary studies show that it can increase the GH level in healthy elderly people or obese individuals, and improve lean body mass.

Gastrointestinal Diseases:

It is experimentally used for the repair of gastric ulcers or mucosal damage.

Anti - aging Field:

Some non - clinical studies explore its role in improving aging - related metabolic decline.

IV. Dosage Forms and Administration Methods

Common Dosage Forms

Injection:

Solution type (acetate dissolved in water, 1 - 5 mg/mL), usually administered subcutaneously or intramuscularly. Due to the low oral bioavailability (about 10 - 20%, affected by gastrointestinal enzyme degradation), injection is the main route of administration.

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