Structural characteristics: PNC - 27 contains the HDM - 2 binding domain of amino acid residues 12 - 26 of the p53 protein, linked to a transmembrane - penetrating sequence, also known as a membrane - localizing peptide (MRP). This structural design enables PNC - 27 to penetrate cancer cells and exert its cytotoxic effects.

Mechanism of action: The HDM - 2 protein is expressed on the cell membrane of cancer cells. PNC - 27 binds to the HDM - 2 protein on the cancer cell membrane, and then the HDM - 2 - PNC - 27 complex assembles into oligomers and eventually forms membrane pores. This allows free PNC - 27 molecules to enter the cell through the newly formed membrane pores, and then form pores on the mitochondrial membrane, leading to the rapid death of cancer cells.

In vitro studies: PNC - 27 is cytotoxic to a variety of cancer cell lines in vitro, including human metastatic colon adenocarcinoma cells, transformed rat brain capillary endothelial cells, human cervical cancer cells, human metastatic breast cancer cells, human non - small cell lung cancer cells, and human osteosarcoma cells, etc., while it is non - toxic to non - cancer cells such as rat pancreatic acinar cells.In cell line experiments, for example, in MIA - PaCa - 2 cells, 50 μg/mL of PNC - 27 can induce 100% cell death within 90 minutes.

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