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PEG-MGF, or PEGylated mechano-growth factor, is a variant of insulin-like growth factor 1 (IGF-1). Below is a detailed introduction: Basic Information: Chemical Formula: (C_{121}H_{200}N_{42}O_{39}\) Molecular Weight: 2888.16 g/mol CAS Number: 108174-48-7 Mechanism of Action: PEG-MGF stimulates myoblast division and differentiation into mature muscle fibers, thereby promoting muscle growth and repair. It binds to the IGF-1 receptor on the surface of myoblasts, activating intracellular signaling pathways, promoting cell proliferation and inhibiting apoptosis. Key Functions: Promotes Muscle Growth: Stimulating muscle cell proliferation and differentiation, increasing the number and size of muscle fibers, helps improve muscle mass and strength, and is beneficial for athletes and fitness enthusiasts in enhancing muscle strength and stamina. Accelerates Tissue Repair: Following injuries to muscles, tendons, ligaments, and other tissues, PEG-MGF promotes the repair and regeneration of damaged tissue, shortening recovery time. Enhanced Immune Function: Helps improve the body's immune system and enhance the body's resistance to disease and infection. Improved Metabolism: May have a positive impact on cholesterol and fat metabolism, helping to lower cholesterol levels and reduce body fat. Pharmacokinetic Characteristics: Because PEG-MGF has been pegylated, its half-life is extended from a few minutes of native MGF to 48-72 hours, allowing it to exert its effects in the body longer and reducing dosing frequency. Usage: PEG-MGF is typically present as a lyophilized powder and needs to be dissolved before injection. Subcutaneous or intramuscular injection is generally used, directly injecting the drug into the desired area to ensure local drug concentration.
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