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5-amino-1mq 5mg
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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a synthetic small-molecule compound that acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT).
Product Details
1.Basic Chemical Information
| Item | Details |
|---|---|
| Chemical Formula | C₁₀H₁₁N₂⁺ |
| Molecular Weight | 159.21 g/mol |
| Alternative Name | 5-amino-1-methyl quinolinium |
| Structural Features | The molecular structure contains a quinoline ring, with an amino group at the 5-position and a methyl group at the 1-position. This unique structure enables it to specifically bind to and inhibit the activity of the NNMT enzyme. |
2.Core Mechanism of Action
Its core function is to inhibit the activity of nicotinamide N-methyltransferase (NNMT). This enzyme is highly expressed in adipose tissue. Its overactivation depletes intracellular nicotinamide adenine dinucleotide (NAD⁺) and S-adenosylmethionine (SAM), which are essential for energy metabolism, thereby leading to metabolic disorders.
Inhibiting NNMT exerts dual effects: on the one hand, it elevates intracellular NAD⁺ levels and activates sirtuin 1 (SIRT1), which is known as the "longevity gene"; on the other hand, it optimizes mitochondrial function and enhances cellular metabolism and energy expenditure. Ultimately, it achieves the effect of burning fat while preserving muscle mass.
3.Main Research Application Directions
Metabolism and Weight Loss: Animal experiments have shown that it can reduce the body weight of obese mice by 5.1% and fat mass by 35% without affecting appetite. Meanwhile, it can improve blood lipid and blood glucose levels, and reverse diet-induced obesity, which is expected to provide a new direction for the research on obesity and type 2 diabetes.
Muscle Health and Anti-Aging: In experiments on aged mice, this compound can increase the grip strength of mice by approximately 40% and promote the regeneration of aged muscle tissue, thus holding potential research value for age-related sarcopenia. In addition, the SIRT1 activated by it is associated with longevity, and combined with its anti-inflammatory properties, this compound has become one of the research hotspots in the field of anti-aging.
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