I. Basic Information

Chemical Structure: The amino acid sequence is H-Cys-Pro-Arg-Lys-Pro-Cys-NH2 (a cyclic hexapeptide linked by a disulfide bond).

CAS Number: 146724-25-6.

Molecular Weight: Approximately 669.8 g/mol.

II. Mechanism of Action

·Anxiolytic and Sedative Effects: Regulates the activity of the limbic system (such as the amygdala), reducing anxiety - related behaviors.

·Antidepressant Effects: May act by influencing the release or reuptake of monoamine neurotransmitters (such as serotonin and dopamine).

·Sleep Improvement: Promotes the natural sleep cycle, shortens the sleep - onset time, and improves sleep quality.

·Analgesic and Anti - inflammatory Effects: Inhibits the pain - conduction pathway, alleviating chronic pain or inflammatory responses.

·Regulation of Stress Response: Lowers the level of cortisol (a stress hormone), relieving stress - related symptoms.

III. Potential Applications and Research

1. Mental Health

Anxiety Disorders: Preliminary studies show that Selank can rapidly relieve anxiety symptoms (such as generalized anxiety disorder, social anxiety), and its onset time may be shorter than that of traditional anxiolytics (such as benzodiazepines).

Post - Traumatic Stress Disorder (PTSD): By regulating the stress response pathway, it reduces symptoms such as flashbacks and nightmares.

Depression: It may be used as an adjuvant treatment to improve core symptoms such as low mood and reduced interest.

2.Sleep Disorders

It is used to treat insomnia, especially insomnia related to anxiety or stress. It can improve problems such as difficulty in maintaining sleep and early awakening.

3.Pain Management

Selank has a certain relieving effect on chronic pain (such as neuropathic pain) and has no obvious addiction potential (unlike opioid drugs).

IV. Administration Routes and Dosages

Injection: Subcutaneous or intramuscular injection is the main route, with a relatively rapid onset of action (usually within 15 - 30 minutes), and the effect lasts for several hours to 1 day.

Intranasal Spray: Some studies have attempted nasal mucosal administration, which is convenient and non - invasive, but the bioavailability may be lower than that of injection.

Dose Range: The dosage used is 0.1 - 0.3 mg per time.

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