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SS-31 is a mitochondria-targeted antioxidant peptide that can selectively localize to the inner mitochondrial membrane and interact with cardiolipin. Cardiolipin is crucial for maintaining the normal function of mitochondria. It can act as a proton trap for ATP synthase, promote electron transfer, and enhance the peroxidase activity of cytochrome c.
Product Details
Basic Information:
Chemical Structure: Composed of four amino acids with the sequence H-D-Arg-Dmt-Lys-Phe-NH2, where Dmt is 2,6 - dimethyl - L - tyrosine. The molecular formula is C32H49N9O5, and the molecular weight is 639.8 g/mol.
CAS Number: 338821 - 00 - 6.
Mechanism of action
·Cardiovascular Diseases: In diseases such as cardiac ischemia-reperfusion injury and heart failure, SS-31 can improve the mitochondrial function of cardiomyocytes, reduce oxidative damage, enhance cardiac function, and decrease cardiomyocyte apoptosis.
·Neurodegenerative Diseases: For neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, SS-31 can protect neurons from oxidative stress and mitochondrial dysfunction. It may improve neurological function through mechanisms such as inhibiting neuronal cell death, enhancing synaptic activity, and reducing β-amyloid formation.
·Diabetes and Its Complications: It can improve the mitochondrial function of diabetic patients, reduce insulin resistance, and also has certain therapeutic potential for complications such as neuropathy and nephropathy caused by diabetes.
·Others: In diseases related to abnormal mitochondrial function such as muscle aging, chronic fatigue syndrome, and mitochondrial myopathy, SS-31 also shows potential therapeutic effects.
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