I. Basic Information

Chemical Name: N'-Methyl - N-[2-[[[5-[(dimethylamino)methyl]-2-furyl]methyl]thio]ethyl]-2-nitro - 1,1-ethenediamine

Molecular Formula: C₁₃H₂₂N₄O₃S

Molecular Weight: 314.41 g/mol

CAS Number: 66332-99-0

Appearance: White to off-white crystalline powder

Solubility: Soluble in water, slightly soluble in ethanol, and almost insoluble in ether 

pH value: The pH of a 1% aqueous solution is approximately 6.8 - 7.8

Pharmacological action

Mechanism of action: Selectively block the H₂ receptors on gastric parietal cells, inhibit the gastric acid secretion stimulated by histamine, pentagastrin, etc., including basal gastric acid secretion and nocturnal gastric acid secretion.

Characteristics of Pharmacological Effects:

The effect of inhibiting gastric acid is 5 - 8 times stronger than that of the first - generation H₂ antagonists (such as cimetidine). It takes effect quickly (the peak plasma concentration is reached 1 - 3 hours after oral administration), and the duration of action is about 12 hours.

It has a protective effect on the gastric mucosa and promotes ulcer healing.

2.Formulations and Administration

Oral Preparations: Tablets, capsules. The usual adult dosage is 150 mg per time, twice a day (after breakfast and dinner) or 300 mg taken before bedtime.

Injectable Preparations: For patients who cannot take orally. Intravenous drip or intramuscular injection. The dosage is 50 mg per time, once every 6 - 8 hours.

Formulations and Storage

Formulations: Tablets (150 mg, 300 mg), Capsules, Injections (50 mg/vial), Syrups, etc.

Storage: Store in a tightly closed container in a dry place, protected from light and high temperatures. Injections should be stored away from light.