I. Basic Information

Chemical Name: 9-[(2 - Methoxyethoxy)-methyl]erythromycin

Molecular Formula: C₄₁H₇₆N₂O₁₅

Molecular Weight: 837.05 g/mol

CAS Number：80214-83-1

Properties: The common dosage forms are tablets, capsules, granules and dry suspensions. It is a white or off-white crystalline powder, slightly soluble in water and easily soluble in methanol and ethanol.

II. Pharmacological Effects

1. Antibacterial Spectrum

Gram-positive Bacteria: Streptococcus pneumoniae, Streptococcus hemolyticus, Streptococcus viridans, Staphylococcus aureus (methicillin-sensitive strains).

Characteristics: Still effective against some penicillin-resistant Streptococcus pneumoniae.

Gram-negative Bacteria: Haemophilus influenzae, Moraxella catarrhalis, Bordetella pertussis, Campylobacter jejuni.

Anaerobic bacteria:

Some Peptostreptococcus, Propionibacterium acnes, etc.

2. Mechanism of action

It binds to the 23S rRNA of the 50S subunit of the bacterial ribosome, inhibits peptide chain elongation and bacterial protein synthesis, and belongs to rapid-acting bacteriostatic agents.

Usage and Dosage

Adults Tablets / Capsules 150 mg each time, twice a day; or 300 mg once a day

Granules / Dry Suspensions 150 mg each time, twice a day

Children

Granules / Dry Suspensions: For those with body weight > 24 kg, the dosage is 150 mg each time, twice a day; for those with body weight ≤ 24 kg, the dosage is 5 - 10 mg/kg per day, divided into two administrations.